AGAP2-AS1 (AGAP2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with AGAP2-AS1 include Glioblastoma and High Grade Glioma. Additional gene information for AGAP2-AS1 Gene HGNC (48633)

Symbol: AGAP2-AS1: Name: AGAP2 antisense RNA 1: Type: other: Synonyms: AGAP2 antisense RNA 1, AGAP2-AS1, LOC100130776, PNS, PUNISHER: Species: Human (AGAP2-AS1 EG

SP1 induces high expression of AGAP2-AS1 According to the article and prediction, we found that the transcription factor SP1 may induce the high expression of AGAP2-AS1 (Dong et al. 2018 ). AGAP2-AS1 promoted cell growth, suppressed apoptosis, and caused trastuzumab resistance, whereas knockdown of AGAP2-AS1 showed an opposite effect. MyD88 was identified as a downstream target of AGAP2-AS1 and mediated the AGAP2-AS1-induced oncogenic effects. Mechanistically, the RIP assay revealed that AGAP2-AS1 could bind to CBP, a As the antisense lncRNA of AGAP2, AGAP2-AS1 was found to conversely inhibited cell proliferation and metastasis in EOC cell lines, and low expression of AGAP2-AS1 was correlated with tumor malignant features, indicating that AGAP2-AS1 is a potential tumor suppressor of EOC. Interestingly, AGAP2‐AS1 sponges miR‐4,668‐3p to release SRSF1 in CRC. Furthermore, in the rescue functional assay, miR‐4,668‐3p down‐regulation exacerbated the malignant behaviors of AGAP2‐AS1‐depleted CRC cells, whereas such effects were further offset by SRSF1 knockdown. Conclusions The results indicated that the levels of TBILA and AGAP2-AS1 were significantly reduced in postoperative samples compared to the paired preoperative samples (all, p < 0.05, Fig. 3A-B), whereas there was no statistical difference in SOX2OT levels between the two groups (p > 0.05, Fig. 3C).

23 Mar 2020 AGAP2-AS1 promoted CRC cell proliferation and inhibited apoptosis. Moreover,. AGAP2-AS1 enhanced the chemoresistance of CRC cells to 27 Jul 2019 Silencing Long Non-Coding RNA AGAP2-AS1 Upregulates microRNA-195-5p to Repress Migration and Invasion of Esophageal Cancer Cells 22 Nov 2016 The expression of four lncRNAs in different grades showed that AGAP2-AS1, LINC01198 and MIR155HG were increased with tumor grade, while Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 is an enzyme that in "The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3". Journal of Cell Science. 118 (Pt 15): &n AGAP2-AS1 Silencing Inhibits Proliferation, Migration, and Invasion but Promotes Apoptosis of EC Cells by Decreasing FOSL1 Expression via. Upregulation of 12, ENSG00000229950, TFAP2A-AS1, 1.70E-15, 8.59E-13, 1.89. 13, ENSG00000138792 246, ENSG00000255737, AGAP2-AS1, 8.44E-10, 1.70E-07, -1.53.

AGAP2‐AS1 can be activated by transcript factor FOXP1. A and B, FOXP1 expression level at protein and RNA level by Western blotting and qPCR, respectively, when HTR‐8/SVneo cells were transfected with FOXP1‐specific siRNAs. The AGAP2‐AS1 expression level was tested by qPCR after treated with siRNAs against AGAP2‐AS1 (B, right panels).

AGAP2-AS1 inhibits CCA cell proliferation, colony formation, and promotes apoptosis. In addition, we also studied the molecular mechanism of AGAP2-AS1 in CCA cells and found potential targets.

Therefore, si-AGAP2-AS1 1, 2 and pcDNA-AGAP2-AS1 were used for all subsequent AGAP2-AS1 knockdown or overexpression experiments. SP1 induces high expression of AGAP2-AS1 According to the article and prediction, we found that the transcription factor SP1 may induce the high expression of AGAP2-AS1 (Dong et al. 2018 ).

Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test. Title: AGAP2-AS1 regulates AGAP2 mRNA levels Abstract: AGAP2-AS1 is an antisense lncRNA situated in the 3’ end of AGAP2.

Results: AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Furthermore, knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and … AGAP2-AS1 was upregulated in MSC-cultured cells, and knockdown of AGAP2-AS1 reversed the MSC-mediated trastuzumab resistance. Furthermore, MSC culture … 2017-02-16 2019-05-14 2017-02-16 AGAP2-AS1 is Upregulated in NSCLC Tissues To determine whether AGAP2-AS1 is involved in NSCLC tumorigenesis, We determined the ex-pression levels of AGAP2-AS1 in NSCLC tissues and matched normal lung tissues by RT-qPCR. As shown in Figure 1, the results showed that the me-dian expression level of AGAP2-AS1 was higher in 2016-05-19 Prostate cancer remains a significant cause of cancer-related deaths in male population.
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GeneCards - The Human Gene Compendium Long non-coding RNA (lncRNA) AGAP2-AS1 acts as an oncogene in several types of cancers. However, the role and mechanism of AGAP2-AS1 in papillary thyroid carcinoma (PTC) remain unclear. Thus, in this study, we aimed to explore the role of AGAP2-AS1 in PTC. Our results showed that AGAP2-AS1 was signi … AGAP2-AS1 could promote breast cancer growth and trastuzumab resistance by activating the NF-κB signaling pathway and upregulating MyD88 expression. Therefore, AGAP2-AS1 may serve as a novel biomarker for prognosis and act as a therapeutic target for the trastuzumab treatment.
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AGAP2-AS1 expression was upregulated and associated with poor prognosis of NSCLC. To investigate lncRNA expression levels in NSCLC tissues compared with normal tissues, we first analyzed the 2017-02-16 · AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Furthermore, knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets. Click the + buttons to view associations for AGAP2-AS1 from the datasets below. If available, associations are ranked by standardized value AGAP2-AS1 dysregulation and characterize the mech-anism by which AGAP2-AS1 regulates its targets in the GC cells. Taken together, the obtained findings may provide new insights into the critical role of the lncRNA AGAP2-AS1 in human GC tumorigenesis and progression.

AGAP2-AS1 demonstrated higher expression in tumor tissues compared with normal tissues (P<0.001; Fig. 1A). Additionally, the expression of AGAP2-AS1 was analyzed in 72 pairs of ccRCC tissues and non-cancerous adjacent tissues using Wilcoxon singed-rank test.

It is becoming now more widely accepted that 3’ antisense lncRNAs can modify the expression of their gene counterparts and we demonstrate here that this is the case as well for the tandem AGAP2 – AGAP2-AS1. 2021-02-18 2021-02-01 AGAP2-AS1 leads to a decrease in cell proliferation and migration, along with the repression of invasion and tumorigenesis.7,8 However, it remains unknown as to whether AGAP2-AS1 inﬂuences cancer progression in EC. Additionally, microRNAs (miRNAs), endogenous non-protein-cod- AGAP2-AS1 dysregulation and characterize the mech-anism by which AGAP2-AS1 regulates its targets in the GC cells. Taken together, the obtained findings may provide new insights into the critical role of the lncRNA AGAP2-AS1 in human GC tumorigenesis and progression. Methods Tissue samples and cell lines Fifty paired GC and adjacent nontumor Complete information for AGAP2-AS1 gene (RNA gene), AGAP2 antisense RNA 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Select categories you would like to watch. Updates to this gene will be send to {{ username }} The interaction of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs has been implicated in various types of cancers, including esophageal cancer (EC).

To investigate lncRNA expression levels in NSCLC tissues compared with normal tissues, we first analyzed the 2017-02-16 · AGAP2-AS1 was highly expressed in the GC tissues and cell lines, and patients with higher AGAP2-AS1 expression had a poorer prognosis and shorter overall survival. Furthermore, knockdown of AGAP2-AS1 significantly inhibited GC cell proliferation, migration, and invasion in vitro and tumor growth in vivo. AGAP2-AS1 has 521 functional associations with biological entities spanning 3 categories (chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 15 datasets. Click the + buttons to view associations for AGAP2-AS1 from the datasets below. If available, associations are ranked by standardized value AGAP2-AS1 dysregulation and characterize the mech-anism by which AGAP2-AS1 regulates its targets in the GC cells.